Histone H2B ubiquitination: the cancer connection.
نویسنده
چکیده
Post-translational modifications of histones play a critical role in gene expression control. Ultimately, cancer is a disease of aberrant gene expression. Accordingly, several histone-modifying enzymes have been described as proto-oncogenes or tumor suppressors. Recent reports, including one from Shema and colleagues (pp. 2664- 2676) in the October 1, 2008, issue of Genes and Development, indicate that deregulation of histone H2B monoubiquitination may contribute to cancer development.
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عنوان ژورنال:
- Genes & development
دوره 22 20 شماره
صفحات -
تاریخ انتشار 2008